Fig. 2

In vivo toxicity of tricarbonyl rhenium complexes JVG045 and ps27. (A-H) Graphs comparing the effect of a dose response of JVG045, ps27, Cisplatin and DMSO control on zebrafish hatching (a-d) and embryo mortality (e-h) from 24 h post fertilisation (hpf) until 120hpf. i Effect of a dose response of JVG045 on zebrafish heartbeats showing no significant difference up to 500 μM compared to DMSO. j BGJ398 is a competitive FGFR1–3 inhibitor [38, 39] acting on multiple FGFRs in the zebrafish embryo and causing developmental defects starting at concentrations as low as 0.5-1 μM. On the other hand, as a putative FGFR1 inhibitor, JVG045 does not cause developmental defects in the zebrafish embryo. Treatment started at 2hpf and images were taken at 24hpf. Results are showed as Mean ± SEM and are representative of at least three independent experiments