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Table 2 Univariable and multivariable cox regression analysis of MIR31HG and its splice variants with clinicopathological features in the Mannheim cohort (HR hazard ratio, CI confidence interval, LVI lymphovascular invasion, Basal high KRT5 expression, Non-basal low KRT5 expression, significant p values are bold)

From: Long noncoding RNA MIR31HG and its splice variants regulate proliferation and migration: prognostic implications for muscle invasive bladder cancer

Factor

Univariable

Multivariable

HR (95% CI)

p

HR (95%CI)

p

Diagnosis Age

 <70 vs. ≥70

0.701(0.406–1.212)

0.2041

–

–

Gender

 Male vs. Female

0.980(0.535–1.795)

0.9485

–

–

Stage

 T2 vs. T3/4

0.401(0.202–0.797)

0.0092

0.445(0.220–0.900)

0.0243

LVI

 Negative vs. Positive

0.550(0.075–4.050)

0.5570

–

–

Lymphnode Status

 Negative vs. Positive

0.547(0.245–1.221)

0.1418

0.694(0.243–1.987)

0.4961

Molecular Subtype

 Basal vs. Non-basal

1.202(0.596–2.422)

0.6073

–

–

MIR31HG

 Low vs. High

1.720(0.681–4.347)

0.2522

–

–

MIR31HGΔE1

 Low vs. High

3.753(1.457–9.664)

0.0063

1.896(0.831–4.329)

0.1294

MIR31HGΔE3

 Low vs. High

2.522(1.235–5.149)

0.0114

2.805(1.293–6.083)

0.0090