Fig. 6
Microbial communities specific for BRAF-mutated and BRAF wt CRC patients. a Representative histologic analysis of patient’s tissues revealing a serrated architecture and the presence of dysplasia in BRAFV600E CRCs (top) and traditional adenocarcinoma features in BRAF wt cases (bottom). Bar, 100um and 50um. b Age (top) and BMI (bottom) distribution in CRC and healthy subjects (n = 15 BRAF wt, 8 BRAFV600E CRC, 13 healthy subjects), Mann-Whitney test. c Rarefaction curve for the analysis of microbial species content in healthy, BRAFV600E and BRAF wt CRC cases. d A-diversity (Shannon index; left) and richness (right) of the three groups of subjects at the genus (top) and species (bottom) level. P values are from Kruskal-Wallis tests. e Firmicutes and Bacteroidetes ratio in the three groups of subjects. ** P < 0.01, one-way ANOVA Tukey’s multiple comparison test. Data are mean ± SEM