Fig. 4

MIEF2 knockdown suppressed OC growth and metastasis in nude mice. a and b Growth curves and weights of xenograft tumors developed from OVCAR3 cells with or without MIEF2 knockdown. Scale bars, 20 μm. c and d IHC staining of MIEF2 and Ki-67 in xenograft tumors developed from OVCAR3 cells with or without MIEF2 knockdown. Scale bars, 20 μm. e TUNEL assay for cell apoptosis in tumor tissues developed from OVCAR3 cells with or without MIEF2 knockdown. Scale bars, 5 μm. f Incidence of lung metastasis of OVCAR3 cells with or without MIEF2 knockdown. Scale bars, 10 μm. *P < 0.05