Fig. 7

Reduced SBF2-AS1 and overexpressed miR-143 suppress the tumor growth in BC nude mice. a The impacts of SBF2-AS1 and miR-143 on MDA-MB-231 tumor growth, the volume of tumor = length × width × height; b Representative images of MDA-MB-231 cell tumors in nude mice; c Statistical results of the weight of MDA-MB-231 cell tumors in each group; d The impacts of SBF2-AS1 and miR-143 on MCF-7 tumor growth, the volume of tumor = length × width × height; e Representative images of MCF-7 cell tumors in nude mice; f Statistical results of the weight of MCF-7 cell tumors in each group; g Ki-67 expression in MDA-MB-231 cell tumors (SABC, × 200); h Statistical results of Ki-67 expression in MDA-MB-231 cell tumors; i Ki-67 expression in MCF-7 cell tumors (SABC, × 200); j Statistical results of Ki-67 expression in MCF-7 cell tumors; k Representative images of TUNEL staining in MDA-MB-231 cell tumors (× 400); l Apoptosis rate in MDA-MB-231 cell tumors; m, Representative images of TUNEL staining in MCF-7 cell tumors (× 400); n Apoptosis rate in MCF-7 cell tumors. The measurement data conforming to the normal distribution were expressed as mean ± standard deviation. One-way ANOVA was used for comparisons among multiple groups, and LSD-t test was used for pairwise comparisons after one-way ANOVA, n = 6 mice, * P < 0.05 vs the si-NC group; # P < 0.05 vs the mimics NC group; & P < 0.05 vs the oe-SBF2-AS1 + mimics NC group