Fig. 2

Direct effect of sunitinib on mccRCC cells. The parental mccRCC cell-line, Caki-1WT, was exposed to different concentrations of sunitinib (SUT) for 24 h. a Significant increase in apoptosis of the cells was observed with increasing concentration of the drug, but the population of non-apoptotic dead cells among different treatment groups were not significant. b With increasing concentrations of SUT, decrease in proliferation was observed with G2M phase using DAPI staining. Data are average of three independent experiments, mean ± SEM and normalised to matched controls. *p < 0.05, **p < 0.01, ***p < 0.001