Skip to main content
Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis

Fig. 3

Effect of Sim on LM3 and LM3-SR cells. (a) CCK8 assay showed the effect of Sim on LM3, LM3-SR and normal liver cells (LO2). (b) Hoechst 33342 staining showing the effect of different concentrations of Sim on LM3 and LM3-SR cells. (c) Flow cytometry showing of effect of different concentrations of Sim on LM3 and LM3-SR cells. The data were represented as mean ± SD. * indicates p < 0.05 vs. CTRL group. # indicates p < 0.05 vs. Sim (10 μM) group. (d) Glycolysis levels after Sim treatment in LM3 and LM3-SR cells, reflected by lactate production and glucose uptake levels. (e) Western blotting analysis of critical proteins. The data were represented as mean ± SD. * indicates p < 0.05 vs. LM3-CTRL group. # indicates p < 0.05 vs. LM3-SR-CTRL group

Back to article page

Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

Contact us