Fig. 6

Serum exosomal circRNA-100,338 can predict lung metastasis in HCC. a The HE stains showed the presence of nodules in the lung tissues. The lung tissue-specific proteins of CK, TIF-1, and Napsin A and the HCC-specific proteins of Hep Par-1, Villin, and Glyp-3 were only detected in lung and pulmonary metastatic tissues, respectively, indicating that the lung nodules were metastases of HCC. b The Kaplan-Meier curves for HCC patients in (Post/Pre)^increase and (Post/Pre)^decrease groups. c Histogram plot and IHC assay (d) showed The MVD and positive rates of Ki-67 expression levels were more observed in (Post/Pre)^high group than that in (Post/Pre)^low group of both primary HCC tissues and pulmonary metastatic tissues. Significance was defined as P < .05 (*P < .05; **P < .01; ***P < .001)