Table 4 ncRNA-mediated regulation of HIF-1α and cancer progression
From: The interplay between HIF-1α and noncoding RNAs in cancer
NcRNAs | Cancer types | Functions | Regulatory mechanisms | Reference |
|---|---|---|---|---|
miR-33b | osteosarcoma | inhibits proliferation and migration | post-transcriptional regulation | [101] |
miR-338-3p | hepatocellular cancer | inhibits viability and induces apoptosis, enhances the sensitivity to sorafenib | post-transcriptional regulation | [102] |
miR-138 | ovarian cancer | inhibits migration and invasion | post-transcriptional regulation | [103] |
miR-576-3p | glioma | inhibits migration and proangiogenic abilities | post-transcriptional regulation | [104] |
miR-18a-5p | lung cancer | promotes radiosensitivity | post-transcriptional regulation | [105] |
miR-3662 | hepatocellular cancer | inhibits warburg effect and growth | post-transcriptional regulation | [106] |
miR-143-5p | gallbladder cancer | inhibits EMT, proliferation, migration and invasion | post-transcriptional regulation | [107] |
miR-143 | cervical cancer | inhibits proliferation, promotes apoptosis | post-transcriptional regulation | [108] |
miR-106a/b | breast cancer | inhibits stem-like cell specific, self-renewal and sphere-forming phenotype | post-transcriptional regulation | [109] |
miR-199a-5p | melanoma | inhibits proliferation, induces arrest | post-transcriptional regulation | [110] |
miR-20b | osteosarcoma | inhibits proliferation and invasion | post-transcriptional regulation | [111] |
miR-18b | melanoma | inhibits proliferation, induces arrest, inhibits the glycolysis | post-transcriptional regulation | [112] |
miR-622 | lung cancer | inhibits migration and invasion | post-transcriptional regulation | [113] |
miR-33a | melanoma | inhibits proliferation, invasion and metastasis | post-transcriptional regulation | [114] |
miR-338 | nasopharyngeal carcinoma | inhibits migration and proliferation | post-transcriptional regulation | [115] |
miR-20b | hepatocellular cancer | inhibits proliferation, inhibits apoptosis | post-transcriptional regulation | [116] |
miR-199a-5p | multiple myeloma | inhibits migration, promotes adhesion, inhibits endothelial cells migration | post-transcriptional regulation | [117] |
miR-199b | prostate cancer | inhibits growth, promotes death | post-transcriptional regulation | [118] |
miR-199a | hepatocellular cancer | inhibits proliferation | post-transcriptional regulation | [119] |
miR-138 | renal cancer | promotes apoptosis, inhibits migration | post-transcriptional regulation | [120] |
miR-22 | colon cancer | inhibits endothelial cell growth and invasion | post-transcriptional regulation | [121] |
lncRNA LINC00152 | gallbladder cancer | promotes migration, invasion and EMT | post-transcriptional regulation | [122] |
lncRNA PVT1 | lung cancer | promotes viability and proliferation | post-transcriptional regulation | [123] |
lncRNA HOTAIR | renal cancer | promotes proliferation, migration and EMT, inhibits apoptosis | post-transcriptional regulation | [124] |
lncRNA ROR | hepatocellular cancer | promotes viability | post-transcriptional regulation | [125] |
lncRNA NEAT1 | osteosarcoma | promotes proliferation and invasion | post-transcriptional regulation | [126] |
lncRNA UCA1 | acute myelocytic leukemia | promotes glycolysis and chemoresistance | post-transcriptional regulation | [127] |
lncRNA PVT1 | gastric cancer | promotes proliferation and invasion | post-transcriptional regulation | [128] |
lncRNA DANCR | nasopharyngeal carcinoma | promotes invasion and metastasis | post-transcriptional activation via ILF3/ ILF2 | [129] |
circPIP5K1A | lung cancer | promotes proliferation and metastasis | post-transcriptional regulation | [130] |
circRNA_0046600 | hepatocellular carcinoma | promotes migration | post-transcriptional regulation | [131] |
miR-214 | lung cancer | promotes invasion, proliferation and migration | transcriptional activation via ING4 | [132] |
miR-206 | lung cancer | inhibits proliferation and angiogenesis, promotes apoptosis | transcriptional inhibition via 14-3-3ζ/STAT3 axis | [133] |
miR-675-5p | glioma | promotes angiogenesis | stabilize the mRNA via HuR | [134] |
lncRNA CPS1-IT1 | hepatocellular cancer | inhibits EMT, proliferation, migration and invasion | transcriptional inhibition via Hsp90 | [135] |
lncRNA PVT1 | gastric cancer | promotes survival, inhibits apoptosis | transcriptional activation via mTOR | [136] |
miR-128 | prostate cancer | inhibits growth and metabolism | translational inhibition via RPS6KB1 | [137] |
lncRNA MEG3 | lung cancer | inhibits malignant transformation | translational inhibition via Akt/p70S6K/S6 aixs | [138] |
lncRNA UBE2CP3 | hepatocellular cancer | promotes proliferation, migration and angiogenesis | translational activation via ERK/p70S6K aixs | [139] |
multiple miRNAs | lung cancer | promotes angiogenesis | post-translational activation via FIH1 | [140] |
miR-135b | head and neck squamous cell carcinoma | promotes proliferation, migration, colony formation and angiogenesis | post-translational activation via FIH1 | [141] |
miR-182 | lung cancer | promotes glucose metabolism and proliferation | post-translational activation via FIH1 | [142] |
miR-31 | colorectal cancer | promotes proliferation, migration and invasion | post-translational activation via FIH1 | [143] |
miR-592 | hepatocellular carcinoma | inhibits glycolytic metabolism and proliferation | post-translational inhibition via WSB1 | [144] |
miR-543 | osteosarcoma | promotes glycolytic metabolism and proliferation | post-translational activation via PRMT9 | [145] |
miR-183 | glioma | N.A. | post-translational activation via IDH2/α-KG axis | [146] |
miR-23b | glioma | promotes proliferation and migration, inhibits apoptosis | post-translational activation via VHL | [147] |
miR-145 | colorectal cancer | inhibits proliferation, migration and invasion | post-translational inhibition via Akt/ERK axis | [148] |
miR-30e | breast cancer | inhibits proliferation, migration and invasion | post-translational inhibition via IIRS1/Akt/ERK axis | [149] |
miR-26a | hepatocellular cancer | inhibits angiogenesis | post-translational inhibition via PIK3C2α/Akt axis | [150] |
miR-99a | breast cancer | inhibits migration, invasion, sphere formation | post-translational inhibition via mTOR signals | [151] |
lncRNA ENST00000480739 | pancreatic cancer | inhibits invasion | post-translational inhibition via OS9 | [152] |
miR-22 | chronic myelogenous leukemia | enhances the sensitivity to imatinib | block HIF-1α nuclear transfer via IPO7 | [153] |
lncRNA H19 | multiple myelom | promotes hypoxia-induced adhesion on the stroma | promotes HIF-1α nuclear translocation | [154] |
lncRNA MIR31HG | oral cancer | promotes proliferation, migration and invasion | facilitates the recruitment of HIF-1 complex | [155] |
lncRNA NDRG1-OT1 | breast cancer | N.A. | acts as a scaffold for recruiting HIF-1α | [156] |