Fig. 1

Increased expression of YAP1 in stromal cells in PCa. a Immunofluorescence staining showed the protein expression level and location of FAP and YAP1 in BPH (n = 12) and PCa (n = 25). FAP was displayed in red and YAP1 was displayed in green. The nuclei were stained with DAPI and are shown in blue. The representative image had a magnification of 400 x. b Statistical results show that the proportion of CAFs in PCa tissues (n = 25) is significantly higher than that in BPH tissues (n = 12), p < 0.0001. c Immunohistochemical staining showing the expression level and location of YAP1 and α-SMA in PCa (n = 25). Based on the expression of YAP1 in stromal cells, the IHC results were divided into two groups: Low-YAP1 (n = 9) and High-YAP1 (n = 16). The representative image had a magnification of 200 x. d Statistical results showing the localization of YAP1 in the cells of the “YAP1-High” group (n = 16). YAP1 was localized in the nucleus in 87.65% of tumour cells and 80.36% of stromal cells, while it was localized in the cytoplasm in 12.35% of tumour cells and 19.64% of stromal cells. e The correlation between YAP1 expression in prostate cancer stromal cells and the Gleason Grading. The abscissa represents the positive rate of YAP1 in prostate cancer stromal cells, and the ordinate represents the Gleason Grading. Pearson r = 0.8529, p < 0.0001