Fig. 4

FOXC1 expression is positively correlated with DNMT3B expression and negatively correlated with CTH expression in human HCC tissues. a Representative images showing the FOXC1, DNMT3B and CTH expression in adjacent nontumor tissues and HCC tissues evaluated by IHC staining. Scale bars represent 400 μm (low magnification) and 100 μm (high magnification). b Correlation analysis of the expression of FOXC1 and DNMT3B or CTH in HCC patients in cohort I (left) and cohort II (right). c and e Kaplan-Meier analysis of the association between DNMT3B expression or the concurrent FOXC1 and DNMT3B expression and the recurrence rate or overall survival in both cohorts. d and f Kaplan-Meier analysis of the association between CTH expression or the concurrent FOXC1 and CTH expression and the recurrence rate or overall survival in both cohorts