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Table 1 Summary of clinical trials of IDO1 inhibitors

From: What is the prospect of indoleamine 2,3-dioxygenase 1 inhibition in cancer? Extrapolation from the past

 

Number of initiated clinical trials (n)

Compound/Phase

Combination

Monotherapy

Total

epacadostat

54

5

59

I or I/II

28

31

31

II

19

21

21

III

7

0

7

BMS-986205

18

0

18

I or I/II

7

0

7

II

7

0

7

III

4

0

4

indoximod

12

2

14

I or I/II

8

2

10

II

4

0

4

navoximod

1

2

 

I

1

1

2

KHK-2455

2

0

2

I

2

0

2

PF-06840003

0

1

1

I

0

1

1

LY-3381916

1

0

1

I

1

0

1

DN1406131

0

1

1

I

0

1

1

Total

88

10

98