Fig. 7

Schematic illustration of the NELFE/β-catenin/CSNK2B signaling axis in GC progression. Increased NELFE expression activates the Wnt/β-catenin pathway via upregulation of β-catenin. In the nucleus, interaction of β-catenin with TCF/LEF transcription factors results in activation of CSNK2B expression, which finally promotes GC cell proliferation and metastasis