Fig. 6

HOXA10 bound to the promoter region of TGFB2, activated its transcription and increased its secretion. a ChIP-qPCR assay revealed the potential binding sites of HOXA10 in the TGFB2 promoter region. b-d Dual-luciferase assays demonstrated that HOXA10 activated TGFB2 transcription through direct regulation. e-f TCA protein precipitation and ELISA assays showed that HOXA10 promoted the expression and secretion of TGFβ2 into the extracellular medium. *P < 0.05, **P < 0.01, ***P < 0.001