Fig. 7

Role of candidate splicing factors in TNBC proliferation. Splicing factors knockdown leads to complex dysfunction, resulting in CDCA5 intron retention and downregulation of ESPL1, SMC1 and MAU2. Deficient sister chromatid cohesion results in misalignt chromosomes leading to incomplete mitosis, cells bearing double DNA content, stalling in G1-S transition and ultimately cell death