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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: Long non-coding RNA MAPKAPK5-AS1/PLAGL2/HIF-1α signaling loop promotes hepatocellular carcinoma progression

Fig. 8

PLAGL2/EGFR/AKT pathway mediates the oncogenic effect of MAPKAPK5-AS1. a-c MTT, colony formation and EdU assays showed the effect of PLAGL2 on cell proliferation suppressed by MAPKAPK5-AS1 knockdown. d Flow cytometry showed the effect of PLAGL2 on cell apoptosis induced by MAPKAPK5-AS1 knockdown. e Transwell assay showed the effects of PLAGL2 on migration and invasion of the tumor cells suppressed by MAPKAPK5-AS1 knockdown. f Expression of EMT and EGFR/AKT pathway markers was detected by western blotting to assess the effect of PLAGL2 on EMT process and pathway activity inhibited by MAPKAPK5-AS1 knockdown. *p < 0.05

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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