Fig. 5

Tranilast treatment inhibited CAFs activity and functionality. a Treatment with Tranilast inhibited the activation of CAFs. b Tranilast inhibited the proliferation of CAFs. c Tranilast down-regulated IL-8 at the transcription level. d Tranilast restricted the activation of the NF-κB pathway in NPC cells. e and f Tranilast restricted the proliferation of NPC cells after irradiation. g and h Tranilast restored the radiosensitivity of NPC cells. i and j Tranilast inhibited the proliferation of irradiated NPC cells in vivo. k Represented images of HE staining and α-SMA staining of in vivo experiment were shown. * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001, ns, no significance