Fig. 1
From: The role of the circadian clock in cancer hallmark acquisition and immune-based cancer therapeutics
Circadian markers and their influences on immune-oncology pathways. Diagram represents a simplified depiction highlighting immune cells and receptors of interest. Circadian effects supported by experimental evidence are depicted, with connectors representing the direction of relationships (i.e., arrows represent positive or upregulatory relationships, flat connectors represent negative or inhibitory relationships). Not depicted, disruption or tumor reprogramming of circadian gene signals has been associated with tumor immunophenotype patterns and glucocorticoids have been implicated in poorer response to anti-PD-(L)1 therapy. *“Clock Index” refers to a combined index score of BMAL1, PER1/2/3, CRY1/2, and CLOCK expression levels across multiple cancer types [56]