Fig. 9

Schematic diagram of the protective role of creatine in hypoxic TNBC cells. The schematic diagram illustrating that SLC6A8 is transcriptionally upregulated by p65/NF-κB, thus mediating accumulation of intracellular creatine and maintaining cellular redox balance to promote TNBC cell survival via activating AKT-ERK1/2 signaling under hypoxia