Fig. 7
Sec62 correlates with poor prognosis of the CRC patients. a Representative immunostaining of Sec62 in CRC samples at stage I-IV and adjcent non-cancerous tissues. b The weighted scores of the IHC staining for Sec62 were plotted based on the clinical stages. c-d Kaplan-Meier survival curve for overall survival (c) and disease-free survival (d) of the CRC patients. Statistics were evaluated by the log-rank test. e The survival of the CRC patients with different Sec62 mRNA levels from GSE17538 were analyzed by Kaplan-Meier. f Western blot analysis of Sec62 and β-catenin expression in 16 individual paired CRC tissues. The correlation between Sec62 protein level and β-catenin protein level in the CRC tissues was plotted (Right, n = 16). g Images of the mouse xenograft tumors treated with Sec62 shRNA lentivirus (shSec62) or control shRNA lentivirus (shCtrl) with or without 5-Fu or oxaliplatin. h The tumor growth curves of the mouse xenografts (n = 7). i Sec62 and cleaved caspase 3 were evaluated by IHC in the mouse xenografts