Fig. 7

Model of the RvD1-governed PMN-mediated recruitment of anti-cancer monocytes and reduction in tumor growth. In HPV cancers, tumor-infiltrated PMN contribute to fuel cancer growth also by hampering classical monocyte infiltration and by sustaining chronic inflammation. Supplementation of RvD1 activates PMN anticancer activities and stimulates MCP-1 release that, in turn, increases the recruitment of antitumoral monocytes to reduce cancer growth