Fig. 4

Efficient triple combination to treat KRAS-mutant lung adenocarcinoma cells in vitro. a Treatment strategies in vitro 5 treatments Untreated, 5′-DFCR alone, schedule, schedule + 5′-DFCR and schedule + 5′-DFCR were included. RD: recovery days. b and c: A549 cell growth curve after different treatments, N = 3, on RD21, 2-sided student’s t test was used (*p < 0.05, *** p < 0.001). d and e: H358 cell growth curves after different treatments, N = 2, 2-way ANOVA was used to compare different treatment groups (* p < 0.05). f: representative images of cells acquired by phase contrast-based microscopy at day 13 of the recovery phase (RD13) after senescence associated β-galactosidase staining (200× total magnification)