Table 4 Comparison of CTC-DNA, ctDNA and tumor DNA
From: Current status of ctDNA in precision oncology for hepatocellular carcinoma
| Â | Advantages | Disadvantages |
|---|---|---|
CTC-DNA | Greater allele frequency New mutations | Lower coverage depth Less abundant |
ctDNA | Abundant analysis materials High sensitivity | Lower allele frequency Dying cells source |
Tumor DNA | Gold standard | Non-enough analysis material Unable to reflect tumor heterogeneity Risk and discomfort |