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Table 4 Comparison of CTC-DNA, ctDNA and tumor DNA

From: Current status of ctDNA in precision oncology for hepatocellular carcinoma

  Advantages Disadvantages
CTC-DNA Greater allele frequency
New mutations
Lower coverage depth
Less abundant
ctDNA Abundant analysis materials
High sensitivity
Lower allele frequency
Dying cells source
Tumor DNA Gold standard Non-enough analysis material
Unable to reflect tumor heterogeneity
Risk and discomfort