Table 4 Comparison of CTC-DNA, ctDNA and tumor DNA
From: Current status of ctDNA in precision oncology for hepatocellular carcinoma
| Advantages | Disadvantages | |
|---|---|---|
| CTC-DNA |
Greater allele frequency New mutations |
Lower coverage depth Less abundant |
| ctDNA |
Abundant analysis materials High sensitivity |
Lower allele frequency Dying cells source |
| Tumor DNA | Gold standard |
Non-enough analysis material Unable to reflect tumor heterogeneity Risk and discomfort |