Fig. 8

Exosomal circ_0072083 is associated with TMZ resistance, diagnosis and survival of glioma patients. a The secretion of exosome was confirmed via TEM in serum of TMZ-resistant or sensitive patients. Scale bar: 200 nm. b The concentration and size of exosome from patients were analyzed. c CD63, CD81, TSG101 and GM130 protein levels were examined via western blot in exosome from patients. d Exosomal circ_0072083 expression was detected via qRT-PCR in resistant or sensitive patients. e and f Exosomal circ_0072083 level was measured after incubation of different time points or treatment of different pH values. g The diagnostic value of exosomal circ_0072083 was analyzed using a ROC curve. h The overall survival of patients was analyzed in low or high exosomal circ_0072083 group. ^*P < 0.05