Table 2 Tankyrase-targeted anti-tumor options
From: Tankyrases as modulators of pro-tumoral functions: molecular insights and therapeutic opportunities
| TNKS inhibitor | Target | Type of cancer | References |
|---|---|---|---|
| XAV939 | NS |
Ovarian Breast Neuroblastoma Hepatocellular |
[97] [96, 104] [105] [98, 106] |
| IWR1 | AS | Lung | [94] |
| G007-LK | AS |
Colon Glioblastoma Hepatocellular Melanoma |
[107] [108] [106] [109] |
| OD366 | AS | Colon | [110] |
| OM-1700 | AS | Colon | [111] |
| K-756 | AS | Colon | [102] |
| AZ1366 | NS | Lung | [112] |
| TNKS656 | DB |
Lung Hepatocellular |
[113] [114] |
| RK-582 | NS | Colon | [115] |
| LZZ-02 | NS | Colon | [116] |