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Table 2 Tankyrase-targeted anti-tumor options

From: Tankyrases as modulators of pro-tumoral functions: molecular insights and therapeutic opportunities

TNKS inhibitor Target Type of cancer References
XAV939 NS Ovarian
Breast
Neuroblastoma
Hepatocellular
[97]
[96, 104]
[105]
[98, 106]
IWR1 AS Lung [94]
G007-LK AS Colon
Glioblastoma
Hepatocellular
Melanoma
[107]
[108]
[106]
[109]
OD366 AS Colon [110]
OM-1700 AS Colon [111]
K-756 AS Colon [102]
AZ1366 NS Lung [112]
TNKS656 DB Lung
Hepatocellular
[113]
[114]
RK-582 NS Colon [115]
LZZ-02 NS Colon [116]