Table 2 Tankyrase-targeted anti-tumor options
From: Tankyrases as modulators of pro-tumoral functions: molecular insights and therapeutic opportunities
TNKS inhibitor | Target | Type of cancer | References |
|---|---|---|---|
XAV939 | NS | Ovarian Breast Neuroblastoma Hepatocellular | [97] [105] |
IWR1 | AS | Lung | [94] |
G007-LK | AS | Colon Glioblastoma Hepatocellular Melanoma | [107] [108] [106] [109] |
OD366 | AS | Colon | [110] |
OM-1700 | AS | Colon | [111] |
K-756 | AS | Colon | [102] |
AZ1366 | NS | Lung | [112] |
TNKS656 | DB | Lung Hepatocellular | [113] [114] |
RK-582 | NS | Colon | [115] |
LZZ-02 | NS | Colon | [116] |