Fig. 4

circPVT1 activated CXCL12 signaling via binding miR-455-5p. a Complementary binding sites between circPVT1 and miR-455-5p. b Relative circPVT1 levels in MTC tissues. c Survival rate of MTC patients with high circPVT1 level or low circPVT1 level. d Relative luciferase activity in transfected MTC cells. e Relative circPVT1 and miR-455-5p levels pulled down by Ago2 antibodies. f Relative circPVT1, miR-455-5p, and CXCL12 levels in MTC cells transfected with shNC or shcircPVT1. g & h Relative CXCL12 protein level in MTC cells transfected with shNC or shcircPVT1. *P < 0.05; ** P < 0.01; *** P < 0.001