Fig. 1

High expression of TRAIL in ECSS is positively correlated with lymph node metastasis, stage, and clinical prognosis of patients. a Comparison of differential genes in ESCC tissues (n = 93) and normal esophageal tissues (n = 11) in TCGA database. b-d correlation of TGFB1, CXCL14, and TNFSF10 expression with metastasis, staging and clinical prognosis in patients in TCGA database. e The expression of TRAIL in cancer tissues is higher than in adjacent normal tissues at the mRNA level (n = 83). f Immunohistochemical results showed higher expression of TRAIL in advanced tumors than in early tumor tissues. g High TRAIL expression is negatively associated with clinical survival. NC, negative control, **P< 0.01, *P < 0.05 (unpaired t-test)