Fig. 1

Expression profiles of circRNA in LUSC. a The cluster heat maps displayed an increased and decreased circRNAs. Each column indicates a sample while each row indicates an individual circRNA. The red and blue strips represent high and low expression, respectively; b Scatter plot of circRNAs. c The distribution of differentially expressed circRNAs on chromosomes between LUSC tissues and non-tumor tissues; d Relative expression level of circPVT1 in LUSC tissues (T) and adjacent normal tissues (N) (n = 104) using qRT-PCR. CircPVT1 expression was significantly higher in LUSC tissues, compared to that in adjacent normal tissues; e Diagnostic efficacy of circPVT1 in LUSC tissue was detected via ROC curve analysis; f Relative expression level of circPVT1 in LUSC tissues (T) and adjacent normal serum (N) (n = 110) using qRT-PCR. CircPVT1 expression was significantly higher in LUSC serum, compared to that in adjacent normal tissues; g Diagnostic efficacy of circPVT1 in LUSC serum was detected via ROC curve analysis; h Kaplan-Meier analysis of overall survival curves based on circPVT1expression levels in LUSC patients; i Relative expression level of in lung cancer cell lines and BEAS-2B cell using qRT-PCR. *P < 0.05 versus BEAS-2B cells. Data were showed as mean ± SD, *P < 0.05, ***P < 0.001