Fig. 8

Proposed model for the role of LINC00511 in the regulation of exosome secretion and invadopodia formation, which further facilitating invadopodia membrane extension and extracellular matrix degradation/invasion. LINC00511 induces RAB27B expression and localization to MVBs to drive their anterograde transport, and also induce VAMP7-SNAP23 complex formation to promote exosome secretion, and further promote invadopodia mature and cell invasion. EE, early endosome. MVB, multivesicular body