Fig. 6

mC4BPA stimulation for the accumulation of CD8⁺ and CD4⁺ T cells in mPDAC tumors. a Experimental design of the in vivo experiment using PKCY cells in the orthotopic transplantation model. DMSO (control) and mC4BPA peptide were administered by intraperitoneal injection. b Pancreatic tumor volumes are depicted for the two groups in box-plot histograms. Each volume represents the mean ± SEM. c The representative figures of CD8⁺ T cells in the peripheral of PDAC tumors (left panel; large number of CD8⁺ T cells, right panel; small number of CD8⁺ T cells). Bar, 50 μm. d Number of CD8⁺ cells counting in 2 different high-power fields per mouse are depicted for the two groups in box-plot histograms (Control vs. mC4BPA peptide: *P=0.044, Mann–Whitney–Wilcoxon test). e The representative figures of CD4⁺ T cells in the peripheral of PDAC tumors (left panel; large number of CD4⁺ T cells, right panel; small number of CD4⁺ T cells). Bar, 50 μm. f Number of CD4⁺ T cells counting in 2 different high-power fields per mouse are depicted for the two groups in box-plot histograms (Control vs. mC4BPA peptide: *P=0.033, Mann–Whitney–Wilcoxon test).