Fig. 4

Joint and mutation specific regulation of molecular pathways by KRAS mutations. Binary heatmaps from Ingenuity Pathway Analysis (IPA) of KRAS mutant cells compared to wild-type or BRAF V600E mutant cells. IPA analysis of transcriptome comparisons of (a) KRAS G12C/D/V/G13D versus wild-type, (b) KRAS G12C/D/V and G13D vs BRAF V600E. Proteome DEPs from (c) KRAS G12D/13D vs BRAF V600E comparisons; only these two comparisons had sufficient differentially expressed proteins (DEPs) for IPA analysis. The IPA analysis included DEGs or DEPs fulfillingㅣlog2 FCㅣ > 1, adjusted P value <0.05 and Z-score ≥ 2 or ≤ - 2.