Fig. 20

Differential sensitivity of ABCG2-overexpressed HEK293 cells to FL118, SN-38 and topotecan: Sub-confluent HEK293 cells that have been stably transfected with either pcDNA3 empty vectors (control) or pcDNA3-ABCG2 expression vectors were treated with or without a series of concentrations of FL118 (A), SN-38 (B) and topotecan (C) for 72 h as shown. Cell viability was then determined using MTT assay. Each bar is the mean cell growth ± SD derived from 5 independent parallel testing