Fig. 2

Neutrophil recall and induction of NEtosis by the tumor: Molecules released by tumors, such as chemokines (e.g. IL-8, CXCL6 and CXCL5) and G-CSF glycoprotein function as chemoattractants for neutrophils by drawing them into the tumor site from the bloodstream. Neutrophils that are recalled from the bloodstream adhere to endothelial cells, pass through gaps between endothelial cells and migrate to the tumor site. Once subjected to the influence of the tumor microenvironment, some neutrophils are induced to enter NETosis thus taking a key role in tumor progression