Neutrophil extracellular traps in cancer: not only catching microbes

Table 1 CXCR1/2, PAD4 inhibitors and DNase in preclinical models

PRECLINICAL MODELS OF CANCER
Target	Inhibitor/enzyme	Tumor	References
CXCR1/2	Reparixin	Breast cancer	[42]
PAD4/PD-1/CTLA-4	GSK484/ anti-PD-1 and anti-CTLA-4 checkpoint inhibitors	Breast cancer	[42]
PAD4/ DNA	GSK484/ DNase	Mammary carcinoma (MMTV-PyMT) and pancreatic tumors (RIP1-Tag2)	[57]
PAD4/ DNA	Cl-amidine/ DNase	Lung metastasis	[58]
PAD4/DNA/ NE	PAD4^−/− /DNase / Sivelestad	Lung and colon cancer invasion	[24]
PAD4/PD-1	PAD4^−/− /anti-PD-1 checkpoint inhibitor	Pancreatic tumor (PDAC)	[59]

(Reparixin) CXCR1/2 inhibitor; (GSK484) PAD4 inhibitor; (CI-amidine) PAD inhibitor; (Silvelestad) NE inhibitor; (MMTV-PyMT) mouse model of breast cancer metastasis; (PDAC) pancreatic ductal adenocarcinoma; (RIP1-Tag2) mouse model of β-cell carcinogenesis

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