Fig. 5
From: Molecular features and vulnerabilities of recurrent chordomas
Recurrent chordoma cell lines are susceptible towards HOX/PBX inhibition. (a) Mean IC50 ± SD of HXR9 in U-CH11 (70.26 μM ±17.2) compared to U-CH11R (29.59 μM ±5.5) and (b) unmatched primary (n = 3, 43.91 μM ±12.3) versus recurrent (n = 3, 31.65 μM ±10.4) chordoma derived cell lines. Representative inhibition curves of one representative replicate of the cell lines treated with HXR9 (solid curves) and CXR9 (dotted curves) are depicted. (c) Overall response to HXR9 in chordoma (n = 8; 40.82 μM ±17.2) in comparison to fibroblasts (n = 3; 108.3 μM ±19.9). The inhibition curves of one representative example of fibroblasts are given. (d) Colony formation assay. Values are normalized to the mean amount of colonies after CXR9 treatment (n = 3). Statistical differences were determined by Student’s t-tests (*p < 0.05, **p < 0.01, ***p < 0.001)