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Table 2 Statin use in interventional clinical anticancer studies

From: Statins: a repurposed drug to fight cancer

Cancer Statins Combination agent Population Findings Ref/CTG.ID
Breast cancer Fluvastatin (After the diagnosis) NR 40 Fluvastatin decreased breast tumor proliferation and increased apoptosis [47]
Atorvastatin (After the diagnosis) NR 42 Atorvastatin decreased breast cancer proliferation by influencing the expression of cyclin D1 and p27 [48]
Simvastatin (After the diagnosis) FAC 60 Simvastatin may improve the efficacy of FAC in LABC patients [49]
Simvastatin (After the diagnosis) NR 50 NR NCT03454529
Prostate cancer Fluvastatin (After the diagnosis) NR 33 Fluvastatin is associated with promising effects on tumor cell apoptosis [50]
Atorvastatin (After the diagnosis) ADT 400 NR NCT04026230
Gastric cancer Simvastatin (After the diagnosis) Cisplatin/Capecitabine 244 Adding simvastatin to capecitabine–cisplatin did not increase PFS in patients with gastric cancer [51]
Pravastatin (After the diagnosis) ECC 30 Adding pravastatin to ECC did not improve outcome in patients with advanced gastric cancer [52]
Lung cancer Simvastatin (After the diagnosis) Gefitinib 106 Simvastatin may improve the efficacy of gefitinib in that subgroup of gefitinib-resistant NSCLC patients [53]
Simvastatin (After the diagnosis) Irinotecan/Cisplatin 62 NR NCT00452634
Liver cancer Pravastatin (After the diagnosis) Sorafenib 312 Adding pravastatin to sorafenib did not improve survival in patients with advanced HCC [54]
Atorvastatin (After the diagnosis) NR 240 NR NCT03024684
Pravastatin (After the diagnosis) TAE/5-FU 83 Pravastatin prolonged the survival of patients with advanced HCC [55]
Colorectal cancer Simvastatin (After the diagnosis) Cetuximab/Irinotecan 52 NR NCT01281761
Pancreatic cancer Simvastatin (After the diagnosis) Gemcitabine 106 NR NCT00944463
Ovarian cancer Simvastatin (After the diagnosis) NR 20 NR NCT04457089
Glioblastoma Atorvastatin (After the diagnosis) Radiotherapy/Temozolomide 36 NR NCT02029573
Endometrial cancer Rosuvastatin (After the diagnosis) Megestrol acetate 43 NR NCT04491643
Kidney cancer Atorvastatin (After the diagnosis) Zoledronate 11 NR NCT00490698
Head and neck cancer Atorvastatin (After the diagnosis) NR 414 NR NCT04915183
  1. Abbreviations: ADT Androgen deprivation therapy, CRC Colorectal cancer, DDS Disease-specific survival, ECC Epirubicin, cisplatin and capecitabine, EGFR-TKIs Epidermal growth factor receptor-tyrosine kinase inhibitor, FAC Fluorouracil, adriamycin and cyclophosphamide, GBM Glioblastoma multiforme, GC Gastric cancer, HCC Hepatocellular carcinoma, LABC Locally advanced breast cancer, MM Multiple myeloma, NHL Non-Hodgkin lymphoma, NR Not reported, NSCLC Non-small cell lung cancer, OS Overall survival, PCa Prostate cancer, PFS Progression-free survival, TAE Transcatheter arterial embolization, 5-FU 5-fluorouracil