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Table 1 SCD1 and cancer. Signalling pathways regulated by SCD1 in cancer promotion and development

From: SCD1, autophagy and cancer: implications for therapy

FUNCTION EFFECT ON CANCER CELLS SIGNALLING PATHWAYS INVOLVED REFERENCES
TUMOR FORMATION PROLIFERATION EGFR
ERK1/2 MAPK
PI3K/AKT
CYCLIN D1/CDK4
[60,61,62, 64]
TUMOR GROWTH PROLIFERATION EGFR
ERK1/2 MAPK
PI3K/AKT
CYCLIN D1/CDK4
[61, 62, 65]
TUMOR METASTASIS MIGRATION AND INVASION PI3K/AKT
GSK3-Β/Β-CATENIN
[60, 63]
TUMOR SUBSISTENCE MAINTENANCE OF STEM PROPERTIES WNT/Β-CATENIN/HIPPO
NF-ΚB/ALDH1A1
[63, 69,70,71,72]