SCD1, autophagy and cancer: implications for therapy

Table 1 SCD1 and cancer. Signalling pathways regulated by SCD1 in cancer promotion and development

FUNCTION	EFFECT ON CANCER CELLS	SIGNALLING PATHWAYS INVOLVED	REFERENCES
TUMOR FORMATION	PROLIFERATION	EGFR ERK1/2 MAPK PI3K/AKT CYCLIN D1/CDK4	[60,61,62, 64]
TUMOR GROWTH	PROLIFERATION	EGFR ERK1/2 MAPK PI3K/AKT CYCLIN D1/CDK4	[61, 62, 65]
TUMOR METASTASIS	MIGRATION AND INVASION	PI3K/AKT GSK3-Β/Β-CATENIN	[60, 63]
TUMOR SUBSISTENCE	MAINTENANCE OF STEM PROPERTIES	WNT/Β-CATENIN/HIPPO NF-ΚB/ALDH1A1	[63, 69,70,71,72]

ISSN: 1756-9966