Fig. 3
Created with BioRender.com. The bidirectional arrow represents the interaction between TIGIT and its ligands. The thickness of the arrow represents affinity between TIGIT and its common ligands. TIGIT exerts a coinhibitory effect after engagement with its ligands CD155, CD112, CD113, and Nectin4. The phosphorylated Y225 of TIGIT binds to cytosolic adapter Grb2 and β-arrestin 2 after engaging with its ligands, leading to recruitment of SHIP1, which eventually influences cytokine secretion by regulating several signaling pathways, such as PI3K, MAPK, TRAF6, and NF-κB