Fig. 8

A mechanism of the CIRP-enhanced Wnt/β-Catenin Signaling Pathway. Abnormally increased cytoplasmic CIRP in NSCLC cells promotes CTNNB1 protein expression through post-transcriptional regulation. That is, it binds to the 5′-UTR and 3′-UTR of CTNNB1 mRNA to increase its mRNA stability and facilitate its IRES-dependent translation. The elevated CTNNB1 protein persistently activates the Wnt/β-catenin signaling pathway which results in an increase in downstream oncogene expression and promotes NSCLC progression