Fig. 1

PFKFB4 is amongst the pivotal kinases in ccRCC. A) Workflow of candidate gene selection in the current study and derived from which was B) Functional network of kinase genes enriched in the current study; C) Plotting of area under curve (AUC) for overall survival (OS) in the Cancer Genome Atlas (TCGA) clear-cell renal cell carcinoma (KIRC) dataset against that in International Cancer Genome Consortium (IGCG) ccRCC dataset; D) Heatmap showing expressional correlations between candidate genes in (C); E) Forest plot of hazard ratio (HR) of candidate genes on progression-free survival; F) Heatmap showing expressional correlations between candidate genes in (E); G) Venn diagram of common genes from (D) and (F); H) Reproduced from TCGA dataset, shown was PFKFB4 expression in cancers with ccRCC highlighted; I) Reproduced from TCGA dataset, shown was deferential expression of PFKFB4 in paired normal and cancerous tissues with ccRCC highlighted