Fig. 6

MYSM1 is positively correlated with miR-200 family members and CDH1 in vivo. A MYSM1 is differentially expressed in paired adjacent normal (N), primary tumor (T) and metastatic (M) tissues from 41 CRC patients. Scatter plot showing the relative MYSM1 mRNA level. The statistical data (means and SDs) are shown in the table (right). B Representative data of MYSM1 expression patterns at the mRNA level (upper) and protein level (lower) in CRC patients. C-E Scatter plots of the miR-200b, miR-200a and miR-429 levels (C); the miR-200c and miR-141 levels (D); and the CDH1 and vimentin mRNA levels (E) in 41 paired CRC patient specimens. In A-E, the data are shown as the means ± SDs (N. S., no significance; *P < 0.05, **P < 0.01 and ***P < 0.001, n = 3 independent experiments). F-H Correlation analyses of MYSM1 with the miR-200b cluster (F), MYSM1 with the miR-200c cluster (G) and MYSM1 with CDH1 (left) and vimentin (right) (H). The Spearman rank correlation test was used to determine the statistical significance. The data are presented as the correlation coefficient “r” (***P < 0.001)