Fig. 3
INMT inhibitor DMT suppresses CRPC growth and development. A The structure of DMT. B MTT assay for the proliferation rates of INMT-KD and control Myc-CaP cells cultured in charcoal-treated medium and treated with vehicle or DMT at different concentrations for 72 h. C MTT assay for the proliferation rates of INMT-KD and control DU145 cells treated with vehicle or DMT at different concentrations for 72 h. D-E 1 × 106 Myc-CaP cells were inoculated s.c. into the flank of castrated FVB male mice, 3 days later followed by treatment with vehicle or DMT, i.p., 50 mg/kg/day (D). Twenty one days after cell inoculation mice were sacrificed and tumor were collected and weighted (E). *, P < 0.05; **, P < 0.01