Fig. 7

p65 promoted DNMT1 transcription and induced miR-378a-3p silencing mediated by DNA hypermethylation. A mRNA expression of miR-378a-3p was detected in different HCC cells transfected with control or p65. B The mRNA levels of DNMT1 were detected in HCC cells transfected with control or p65. C The relationship between DNMT1 and p65 in the GEPIA database. D, E Schematic diagram of binding sites from the JASPAR databases. F, G Detecting the function of p65 on the DNMT1 promoter by luciferase reporter and ChIP assays. *P < 0.05; **P < 0.01; ***P < 0.001