Fig. 1

High expression of SETD1A correlates with a poor prognosis in NSCLC patients. A, SETD1A transcript levels in normal lung tissues (n = 108) and NSCLC tissues (n = 1037) from TCGA. NSCLC group consists of 535 LUAD tissues and 502 LUSC tissues. Data are presented as median (interquartile). Significance was determined using Mann-Whitney U test. B, SETD1A transcript levels in paired normal lung tissues (n = 106) and NSCLC tissues (n = 106) from TCGA. C, SETD1A protein expression in normal lung tissues (n = 111) and primary NSCLC tissues (n = 111) from CPTAC. D, Representative images of immunohistochemical (IHC) staining of SETD1A in normal lung tissues and NSCLC tissues. Scale bar, upper 100 μm, lower 10 μm. E, Quantification of SETD1A protein expression according to IHC scores in normal lung tissues and NSCLC tissues. F-G, Patients with high SETD1A expression have a poorer overall survival (F) and first progression survival (G) according to Kaplan Meier-plotter (http://kmplot.com/analysis/index.php?p=service&cancer=lung). **P < 0.01.