Targeting strategies for oxaliplatin-induced peripheral neuropathy: clinical syndrome, molecular basis, and drug development

Table 2 Characteristics of acute and chronic OIPN

Characteristics	Acute OIPN	Chronic OIPN	References
Incidence rate	85–96%	40–93%	[7, 10, 11, 15,16,17,18]
Duration	Within hours of infusion and lasting for the following 7 days	Within 6–12 months, or even lasting for 5 years	[7, 10, 11, 15,16,17,18]
Typical feature	Cold-sensitive peripheral paresthesia, motor symptoms	Acute OIPN symptoms and the “coasting” phenotype	[7, 11, 19]
Mechanism	Na_v channel activation	Sensory neurons death, mitochondrial damage, oxidative stress, glia activation, and neuroinflammation, etc.	[13, 14, 21]

ISSN: 1756-9966