Characteristics | Acute OIPN | Chronic OIPN | References |
---|---|---|---|
Incidence rate | 85–96% | 40–93% | |
Duration | Within hours of infusion and lasting for the following 7 days | Within 6–12 months, or even lasting for 5 years | |
Typical feature | Cold-sensitive peripheral paresthesia, motor symptoms | Acute OIPN symptoms and the “coasting” phenotype | |
Mechanism | Nav channel activation | Sensory neurons death, mitochondrial damage, oxidative stress, glia activation, and neuroinflammation, etc. |