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Table 2 Characteristics of acute and chronic OIPN

From: Targeting strategies for oxaliplatin-induced peripheral neuropathy: clinical syndrome, molecular basis, and drug development

Characteristics Acute OIPN Chronic OIPN References
Incidence rate 85–96% 40–93% [7, 10, 11, 15,16,17,18]
Duration Within hours of infusion and lasting for the following 7 days Within 6–12 months, or even lasting for 5 years
Typical feature Cold-sensitive peripheral paresthesia, motor symptoms Acute OIPN symptoms and the “coasting” phenotype [7, 11, 19]
Mechanism Nav channel activation Sensory neurons death, mitochondrial damage, oxidative stress, glia activation, and neuroinflammation, etc. [13, 14, 21]
  1. OIPN Oxaliplatin-induced peripheral neuropathy