OIPN | Comments | Reference |
---|---|---|
Risk factors associated with OIPN | Age; comorbid health conditions: decreased creatinine clearance, smoking, etc.; raised BMI; low serum albumin; and baseline neuropathy | |
Medication: cardiovascular especially beta blockers; use of opioids | ||
Quantitative sensory testing deficits in patients | ||
Thermal hyperalgesia | [40] | |
Neurofilament light chains in plasma or serum samples | ||
Genetic polymorphisms associated with OIPN | GSTP1 gene (Ile105Val polymorphism), cytochrome P450 enzymes, OCT2, ABCC2, and AGXT | |
SCN4A (rs2302237); SCN10A (rs1263292) associated with an increased incidence of acute oxaliplatin-induced CIPN | [51] | |
SCN9A (rs6746030) protected against severe oxaliplatin-induced CIPN | [52] |