Fig. 7

The expressions of SOX2, USP7, and HIF-1α in chemo-resistant and -sensitive CC tissues and the role of lnc-RP11-536 K7.3 in glucose uptake and angiogenesis. A Representative images of immunohistochemistry of SOX2, USP7, and HIF-1α in CC tissues. B The high expressions of SOX2, USP7, and HIF-1α in 168 oxaliplatin-resistant and 182 oxaliplatin-sensitive human colon cancer tissues. C FISH and immunofluorescence assay were conducted on human chemo-resistant and -sensitive CC tissues. Thirty pairs of human CC tissues were used. D Representative images of PET/CT in human chemo-resistant and -sensitive CC tissues. E-F The relationship between SUVmax value of PET/CT image and lnc-RP11-536 K7.3 expression. 100 colon cancer patients were tested in this experiment. G FISH and immunofluorescence assay were carried out on human chemo-resistant and -sensitive CC tissues. H Schematic illustration of the role of the lnc-RP11-536 K7.3/SOX2/USP7/HIF-1α signaling axis in regulation of glycolysis, angiogenesis, and sensitivity to oxaliplatin