Cell line | SAHA | FK228 |
|---|
IC50 a (μM) | IC50 a (μM) | % TUNEL positive | IC50a (nM) |
|---|
(72 h) | (96 h) | cellsb | (72 h) |
|---|
SYO-1 | 0.7 ± 0.1 | 0.5 ± 0.01 | 10.5 ± 1 | 4.4 ± 0.8 |
CME-1 | 0.8 ± 0.2 | 0.7 ± 0.2 | 6.7 ± 0.2 | 4.2 ± 0.1 |
MoJo | 1.4 ± 0.5 | 0.8 ± 0.2 | -c | 8.4 ± 1.6 |
Yamato-SS | 0.5 ± 0.2 | 0.5 ± 0.2 | -c | 3.8 ± 0.7 |
- a IC50, drug concentration inducing 50% inhibition of cell growth after the indicated time of exposure to the drug. IC50 values are expressed as mean ± SE from at least two biological replicates performed in duplicate. Raw data are reported in Supplementary Table S3
- b Apoptosis was assessed by TUNEL assay after drug treatment (2 μM) for 72 h in SYO-1, CME-1 and Yamato-SS cells and 96 h in MoJo cells. Mean percent of positive cells ± SE from at least two biological replicates are reported
- c - no TUNEL staining detected in drug-treated cells
