Fig. 2
From: Ubiquitin-specific peptidase 37: an important cog in the oncogenic machinery of cancerous cells
Overview of the role of USP37 in stabilizing various oncoproteins in different cancers. A USP37 interaction with the PLZF moiety of the PLZF/RARA fusion protein and its stabilization by suppressing the effects of arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) treatment through deubiquitination and promoting cell transformation in APL. B USP37 direct interaction with c-MYC and its stabilization in a DUB activity-dependent manner for further regulation of cell proliferation and the Warburg effect in lung cancer. C USP37 interaction with 14–3-3γ and its stabilization via deubiquitination for further cell growth and proliferation. D USP37 interaction and stabilization of HIF2α and its involvement in oncogenesis in clear cell renal cell carcinoma