Fig. 9

Schematic representation of biological properties of PCa cells overexpressing different NF-YA isoforms. Localized and metastatic PCa tumors are mainly composed by cells expressing high levels of NF-YAs (NF-YAs^high), which is fundamental for their survival and enhances proliferation and interaction with ECM. Both NF-YAs^high and NF-YAl^high cells are able to invade ECM with different patterns and form distant lung metastases. NF-YAl^high cells have increased migration ability, consistently with higher NF-YAl expression in PCa CTCs. Stratification of patients based on NF-YAs^high signature predicts poor clinical outcome. Created with BioRender.com (Biorender, RRID:SCR_018361)